| 1. | Objective l . to investigate the mechanism of the different influence of the intrathoracic pressure change ( itpc ) on the two ventricular fillings and the motion of interventricular septum
目的1建立模拟实验模型，观察胸压变化对左、右心充盈及室间隔运动的影响，从力学角度验证我们提出的呼吸影响心功能机制新假说； 2 |
| 2. | 3 . effects of intrathoracic pressure change on the hemodynamics and the motion of ivs in patients with pe to observe the respiration - related hemodynamic changes and the ivs motion in 10 patients with pe with or without cardiac tamponade using echocardiographic technique . 4
心包积液时呼吸对血流动力学及室间隔运动的影响用超声心动图观察心包积液伴有或不伴有心包填塞患者川例的血流动力学改变及室间隔随呼吸运动倩况，计算rvi值，并与正常人进行对照。 |
| 3. | With the pressure in the simulated right ventricle ( srv ) and simulated left ventricle ( slv ) kept constant ( standard pressure condition for model iii ) , each step of pressure decrease in the scc from 0 mmhg to - 5 mmhg , the sivs moved leftwards ( to the slv direction ) in a corresponding position and from 0 mmhg to + 5 mmhg , the sivs swung left - and rightwards at amplitude of 2 . 2 mm . effects of intrathoracic pressure change on the motion of ivs under the same simulated respiratory
胸压变化对室间隔运动的影响当模拟右心室和左心室压力一定时，模拟胸腔内压力每一次下降（从到一smmhg人模拟室间隔均向左侧移位；当模拟胸腔内压力相同，随模拟右心室压力的升高，模拟室间隔的运动幅度增大，当模拟右心室压力升高到与模拟人心室相等时，模拟室间隔的运动幅度达最大。 |
| 4. | Simulated experiments effects of intrathoracic pressure change on hemodynamics model i and ii tests demonstrated that the same itpc had different actions on the simulated ventricular fillings . the itpc would not change the pressure in the simulated right heart but its volume while it changed the pressure in the simulated left heart without direct influencing on its volume
模拟实验胸压变化对血流动力学的影响3第四军医大学博士学位答辩论文外周静脉压和模拟胸腔压力变化相同时所引起的右心室容积的变化是相同的；当两者同时同步变化时，右心室容积无变化。 |
| 5. | Simulated experiments effects of intrathoracic pressure change on hemodynamics three models that simulated the anatomic arrangement of the venous return systems and chest cavity were established to investigate the hydromechanic principle of the different influence of the itpc on the ventricular fillings . effects of intrathoracic pressure change on the motion of interventricular septum ( ivs ) acuson ' s sequoia 512 ultrasonographic system was used in this study to record the m - mode and two - dimensional cineloop images of the simulated interventricular septum movement with different intrathoracic pressure changes
指标观测观察并记录外周静脉压和模拟胸腔压力分别变化及同时变化时，模拟右心室的容积变化；观察并记录模拟胸腔压力变化时，模拟肺血管床和左心室内压力的变化；用sequoia512超声心动图仪观察胸腔压力变化对模拟心脏室间隔运动的影响。 |
| 6. | Among the pathophysiological mechanisms , the sudden shift from a positie to a negatie intrathoracic pressure plays an important role since it results on the one hand in an increased pressure gradient for systemic enous return and in cardiac preload and on the other hand in a decreased pressure gradient for left - entricular ejection and an increase in left - entricular afterload
在诸多病理生理学机制中，胸内正压向胸内负压的突然转换扮演了重要作用，一方面，是由于增加了体循环静脉回流的压力梯度和心脏前负荷，另一方面，降低了左室射血的压力梯度并增加了左室后负荷。 |
| 7. | New methods for noninvasively detecting pulmonary pressure and left ventricular end - diastolic pressure manometer that measures megative pressure in mmhg was connected with the examined subject through a mask . the manometer is a remodeled sphygmomanometer for routine peripheral arterial blood pressure measurement that is market - available . the examined subjects were asked to carry out muller maneuver slowly so that the intrathoracic pressure decreases gradually while the blood flow of the right ventricular outflow tract observed with pulsed doppler echocardiography at the parasternal short - axis view of the great vessels in the two - dimensional echocardiography
肺动脉压和左室舒张末压无创测定新方法随机选取有肺动脉瓣返流受检者，根据我们提出的假说，人为地降低胸内压（附加胸腔负压） ，当降到肺动脉内压力等于或小于右室压时，肺动脉瓣即可开放，用多普勒超声心动图法可以探查到肺动脉瓣上的前向血流，此时的肺动脉压应该为附加胸腔负压的绝对值加上右室压。 |
